Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection.

B cells modulate systemic responses to Pneumocystis lung infection and 1 protect on - demand hematopoiesis via T cell - independent , innate 2 mechanism when type - I - IFN - signaling is absent

13 HIV infection results in a complex immunodeficiency due to loss of CD4 + T cells, impaired 14 type-I-IFN-responses and B cell-dysfunctions causing susceptibility to opportunistic infection 15 such as Pneumocystis pneumonia and unexplained comorbidities, including bone marrow 16 dysfunctions. Type-I-IFNs and B cells critically contribute to immunity to Pneumocystis lung 17 infection. We recen...

B cells modulate systemic responses to Pneumocystis murina lung infection and protect on-demand hematopoiesis via T cell-independent innate mechanisms when type I interferon signaling is absent.

HIV infection results in a complex immunodeficiency due to loss of CD4(+) T cells, impaired type I interferon (IFN) responses, and B cell dysfunctions causing susceptibility to opportunistic infections such as Pneumocystis murina pneumonia and unexplained comorbidities, including bone marrow dysfunctions. Type I IFNs and B cells critically contribute to immunity to Pneumocystis lung infection. ...

Type I IFNs Act upon Hematopoietic Progenitors To Protect and Maintain Hematopoiesis during Pneumocystis Lung Infection in Mice.

Although acquired bone marrow failure (BMF) is considered a T cell-mediated autoimmune disease, few studies have considered contributing roles of innate immune deviations following otherwise innocuous infections as a cause underlying the immune defects that lead to BMF. Type I IFN signaling plays an important role in protecting hematopoiesis during systemic stress responses to the opportunistic...

Lung Infection Pneumocystis IFNs during Systemic Responses to and Regulation of Hematopoiesis by Type I Prevention of Bone Marrow Cell Apoptosis

Type I interferon signaling and B cells maintain hemopoiesis during Pneumocystis infection of the lung.

Loss of CD4 T cells is the hallmark of HIV infection. However, type I IFN-producing plasmacytoid dendritic cells may also be lost. This results in susceptibility to an opportunistic infection such as Pneumocystis pneumonia. In addition, regenerative bone marrow failure resulting in pancytopenia is another common problem in advanced stage AIDS. This may be linked to both the failing immune syste...